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wgbstools: a computational suite for DNA methylation sequencing data analysiswgbstools allows compact data formats, fragment-level analysis, and visualization to reveal biological structure in DNA methylation sequencing beyond single-CpG analysis, while preserving privacy.
Repeated proliferative events ameliorate age-associated accumulation of DNA damage in HSPCsRepeated proliferative events during the lifetime reduce DNA damage accumulation in HSPCs over aging without impacting their function.
TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentryThis study demonstrates that YAP6SA promotes cardiomyocyte cell cycling through TEAD-independent pathways, suggesting a novel therapeutic approach for heart repair.
Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lungBy stabilizing the ciliary length and preserving the proximal-distal gradient, Notch signaling acts as a key regulator of multiciliated cell homeostasis, a process disrupted during Mycobacterium tuberculosis infection, likely through suppression of the Notch–PROM1 axis.
Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradationA comprehensive analysis of CTLA4 stabilisation by induced proximity of a DUB, provides a template for rigorous analysis of DUB:target pairings in the advancement of ENTAC development pipelines.
Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytializationCerebral deposition of fibrillar amyloid-β is a pathological hallmark of Alzheimer’s disease. Cytotrophoblasts in the placenta produce amyloid β. Amyloid β deposits in preeclamptic placentas, and amyloid β fibrils can detrimentally suppress the syncytialization of cytotrophoblasts.
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